Similarly, Domingo and colleagues also found in a large randomized trial comparing rofecoxib with placebo after primary CRC resection that regular use of low-dose aspirin after CRC diagnosis was associated with a reduced rate of recurrence in patients with PIK3CA-mutated tumors compared with PIK3CA-wild-type tumors (HR = 0.11; 95% CI; 0.001–0.832; P = 0.027) 43. Here, PIK3CA is linked to colorectal carcinoma.