Recent studies have indicated that annexin A2 may be a target for autoantibodies in SLE, SS, RA, and systemic vasculitis, and it has been hypothesized that anti-annexin A2 antibodies can induce thrombosis by activating endothelial cells and inhibiting plasmin generation32, 33, 34. The gene discussed is ANXA2; the disease is necrotizing vasculitis.