UBE2L3 and systemic lupus erythematosus: UBE2L3 genotype data from an ongoing SLE GWAS (T.J.V., data not shown) was imputed with 1000 Genomes reference data, identifying rs140490 as the most strongly associated SNP, located at −270 bp of the promoter region of UBE2L3 (p = 8.6 × 10−14, OR 1.30, 95% CI: 1.21–1.39) (Figure 1A).