UBE2L3 and systemic lupus erythematosus: Although rs140490 genotype did not affect naive, transitional, or memory cell population numbers in SLE-affected individuals, the UBE2L3 risk allele was specifically associated with increased plasmablast and plasma cell number (both p < 0.001, one-way ANOVA) in SLE-affected individuals, but did not influence plasmablast or plasma cell numbers in healthy individuals (Figures 7A and 7B).