NFKB1 and systemic lupus erythematosus: Because the tagging SNP rs140490 affects NF-κB responses in vivo and influences terminal B cell differentiation in SLE, we would predict that rs140490 could have potentially important clinical implications for prognosis in SLE, as well as response to biologic therapies such as anti-CD20 B cell depletion or anti-BLyS treatment.