TRPA1 and diabetic neuropathy: For example, while injection of the glucose metabolite methlyglyoxal (MG) results in a TRPA1-dependent sensory neuropathy in mice (Eberhardt et al. 2012; Andersson et al. 2013) and while MG is elevated in patients with diabetic neuropathy, it has not yet been demonstrated that MG or TRPA1 plays a causative role of any kind in diabetic neuropathy.