To better unravel the mechanisms involved in the peroxisomal and MCT2-dependent disease initiation, we have analysed the cellular trafficking of MCT2 and demonstrated that GP70, the previously described MCT2 chaperone, is barely expressed in the PCa cells, indicating that MCT2 should rely on an alternative chaperone for its proper function in these cells. Here, SLC16A7 is linked to posterior cortical atrophy.