As shown in Fig. 8, most of these node proteins are related to virus infection such as Nuclear factor of kappa light polypeptide enhancer in B-cells 1, Natural cytotoxicity triggering receptor 1, Suppressor of cytokine signaling 1, Epidermal growth factor receptor, Vitamin D3 receptor, CD80, Tyrosine-protein kinase SYK, and SMAD family member 250, 51, 52, 53, 54, 55, 56, 57, 58. Here, SOCS1 is linked to viral infectious disease.