ADRB1 and diabetes mellitus: Further analysis indicated that age, heart rate, smoking, hypertension, diabetes mellitus, coronary heart disease, chronic renal disease, valvular heart disease, glycosylated hemoglobin and Hs-CRP were closely associated with SHF morbidity, however, ADRB1 and GRK5 variants did not present significantly independently associated with the risk of SHF morbidity (see Table 2).