Further analysis indicated that age, heart rate, smoking, hypertension, diabetes mellitus, coronary heart disease, chronic renal disease, valvular heart disease, glycosylated hemoglobin and Hs-CRP were closely associated with SHF morbidity, however, ADRB1 and GRK5 variants did not present significantly independently associated with the risk of SHF morbidity (see Table 2). The gene discussed is GRK5; the disease is diabetes mellitus.