Considering that ADRB1 and GRK5 polymorphisms were represented differently among ethnicities, and influenced the β-blocker treatment effect with systolic heart failure (SHF), thus our study was designed to identify whether GRK5 Gln41Leu and ADRB1 Arg389Gly polymorphisms would affect on SHF in Chinese population. This evidence concerns the gene ADRB1 and systolic heart failure.