Further analysis indicated that age, heart rate, smoking, hypertension, diabetes mellitus, coronary heart disease, chronic renal disease, valvular heart disease, glycosylated hemoglobin and Hs-CRP were closely associated with SHF morbidity, however, ADRB1 and GRK5 variants did not present significantly independently associated with the risk of SHF morbidity (see Table 2). This evidence concerns the gene GRK5 and heart valve disorder.