Our data revealed that the Cezanne status was an independent negative prognostic factor for OS (HR = 0.352, 95% CI = 0.226-0.546, P < 0.001) and TTR (HR = 0.354, 95% CI = 0.237-0.528, P < 0.001) in HCC patients (Table 3). The gene discussed is TTR; the disease is hepatocellular carcinoma.