AFP and hepatocellular carcinoma: In addition, Kaplan-Meier analysis demonstrated that low Cezanne expression (P < 0.001), high AFP level (P = 0.049), high GGT level (P = 0.006), liver cirrhosis (P = 0.012), larger tumor size (P < 0.001), multiple tumor number (P = 0.025), satellite nodule (P = 0.009) and vascular invasion (P < 0.001) were significantly associated with shorter TTR in HCC patients (Table 3).