Based on Cezanne expression and serum AFP values, HCC patients were categorized into three groups with different recurrent risks and prognosis: group I, Cezanne (−) and AFP > 20 ng/mL, poor prognosis and high-risk of recurrence; group II with Cezanne (−) and AFP ≤ 20 ng/mL, or Cezanne (+) and AFP > 20 ng/mL, intermediate prognosis and intermediate-risk of recurrence; group III with Cezanne (+) and AFP ≤ 20 ng/mL good prognosis and low-risk of recurrence (Figure 6). Here, AFP is linked to hepatocellular carcinoma.