Lastly immunohistochemical analyses revealed that the microvascular network of Calu-6 tumors from hrIL-27-treated mice was similar to that of the controls whereas that of SK-MES tumors from hrIL-27-treated mice was clearly impaired (Figure 2C and 2D) (Table 3) in association with a weakened laminin network and a faint, but distinct cancer cell expression of IFNγ (Figure 3A). This evidence concerns the gene IFNG and cancer.