Nuclear and cytoplasmic SNAI1 stainings were dramatically and moderately reduced respectively, and the percentage of cancer cells endowed with a distinct to strong nuclear SNAI1, SNAI2, and ZEB1 staining also significantly (P < 0.05) decreased following hrIL-27 treatment (Figure 3D), whereas E-Cadherin expression was reinforced in tumors from hrIL27-treated mice (Figure 3D) (Table 3). Here, ZEB1 is linked to cancer.