The myeloid cell mediated anti-lung cancer effects of IL-27 may be exerted in humans, since in our samples IL-27R is not only expressed by cancer cells, and microvessels, but also by CD15+ granulocytes, CD68+ monocytes/macrophages and CD11c+ myeloid dendritic cells scattered in the stroma or arranged in TLS. This evidence concerns the gene CD68 and lung cancer.