Anti-angiogenesis has a marginal or nil role in IL-27's anti-lung cancer efficacy, and apart from a slight IFNγ induction and LAMININ-α5 down-regulation observed in SCC cells, IL-27 even down-regulates the angiogenesis inhibitor THROMBOSPONDIN-1 [33] in SK-MES cells, and up-regulates VE-CADHERIN [34] and the pro-angiogenesis gene TYMP-1, encoding for ECGF1 [35], in Calu-6 cells, but without significant in vivo consequences for tumor vascularity. The gene discussed is CDH5; the disease is lung cancer.