NFATC2 and atrial fibrillation: BMDMs from TLR9−/− mice showed impaired AF-induced NFATc2 translocation (Fig7D and E) and, additionally, the TLR9 blocking nucleotide ODN2088 blocked NFATc2 translocation in J774A.1 macrophages without blocking conidial uptake (Fig7F and Supplementary Fig S8A).