CD8A and malaria: As shown in Figure 2, P. vivax infection reduced the number of CD8+CD45RO+CCR7+ compared with those in malaria-naïve donors (median = 27.0 vs. 274.0 cells/mm3), whereas there were no significant differences in CD8+CD45RO+CD62L+ (median = 30.5 vs. 14.0 cells/mm3) central memory T cells (p = 0.002 and p = 0.120, respectively).