F11 cells were pretreated for an hour with 2 μM AMD, a small molecule inhibitor of gp120 binding to CXCR4 (De Clercq et al., 1994; Donzella et al., 1998), and then a time course experiment was performed cotreating cells with fluorescein-gp120 and AMD. Here, CXCR4 is linked to age-related macular degeneration.