Nees has already been used as an anti-inflammatory drug for treating rheumatoid arthritis and laryngitis for several centuries [8,9], and its major constituent andrographolide exhibits anti-inflammatory effect in LPS-stimulated RAW264.7 macrophages through the suppression of STAT3-mediated inhibition of the NF-κB pathway [10]. Here, NFKB1 is linked to rheumatoid arthritis.