In support of this interpretation, elegant studies have demonstrated that mice with a conditional knockout of ADAM10 in the skin, or in the respiratory epithelium, are resistant to S. aureus mediated dermonecrosis and lethal pneumonia, respectively, yet in both instances, the conditional ADAM10 knockout mice had bacterial burdens which were not statistically different from the wild type mice [68,69]. The gene discussed is ADAM10; the disease is pneumonia.