The similar olfactory abilities among members of the Italian family comprising patients homozygous for the 253 kb deletion, together with the observation that the lowest UPSIT score for homozygous patients was in range in moderate microsmia and not in the range of severe microsmia or of anosmia, may indicate that TMEM16B is not necessary for normal olfaction, in agreement with a previous study on knockout mice for TMEM16B [24]. This evidence concerns the gene ANO2 and Kallmann syndrome.