Most candidate SNVs failed to segregate directly in CeD subjects and only one positive segregation test was observed in the BRK family, in which all CeD cases carried the nonsense c.184C>T (p.G62S) variant in TNFRSF21, although this was not deemed to be statistically significant. This evidence concerns the gene TNFRSF21 and cranioectodermal dysplasia.