RPS6KB1 and cardiovascular disorder: Excessive activation of mTORC1-S6K1 signaling is implicated in acceleration of aging process and age-related diseases including cardiovascular disease and type 2 diabetes mellitus in various animal models [28] and has been demonstrated to be responsible for loss of replicative/regenerative potential and hypertrophy during cell senes-cence, a process called “geroconversion” [29-32].