Although Arg-II, p38, or mTORC1-S6K1 and a crosstalk between Arg-II and mTORC1-S6K1 or between Arg-II and p38 are reported to play a role in endothelial dysfunction in aging and obesity [4, 27], an interaction among the three pathways in vascular endothelial aging and endothelial SASP function is not known. Here, RPS6KB1 is linked to obesity due to melanocortin 4 receptor deficiency.