Consistent with this, AD, PD, and DLB patients have decreased orexin cell numbers compared with age-matched controls (Fronczek et al. 2012)(Thannickal et al. 2007)(Lessig et al. 2010), and FTLD patients have decreased levels of orexin-A (Çoban et al. 2013). Here, HCRT is linked to Lewy body dementia.