HBD and neoplasm: Stimulation of oral squamous cell carcinoma (BHY-OSCC) cell line with HBD-1 resulted in reduction of cell proliferation, whereas HBD-2 and HBD-3 stimulation caused promotion of cell proliferation, indicating that HBD-1 might function as a tumor suppressor gene, while hBD-2 and -3 might be protooncogenes in OSCC [33].