VWF and Arterial thrombosis: Altered platelet adhesion and aggregation due to increased vWF concentration, decreased ADAMTS13 (a metalloproteinase, that cleaves vWF to smaller, less procoagulant forms), increased in vitro platelet aggregation after low concentrations of adenosine diphosphate and/or epinephrine (sticky platelet syndrome) are associated with arterial thrombosis [16,17].