IL6 and Insulin resistance: Regarding the IL-6 (−174 G/C) polymorphism, however, several investigations have reported that the homozygous CC genotype was associated with higher serum IL-6 levels, which is in contrast to studies indicating that the G allele is associated with increased IL-6 secretion in subjects with PCOS, metabolic syndrome, and insulin resistance [12,22,39,44].