Finally, a total of 14 eligible articles with a total of 1665 PCOS patients and 1687 healthy subjects met the inclusion criteria and were included in this meta-analysis [7,14-26], with one study that included both TNF-alpha (−308 G/A) and IL-6 (−174 G/C) polymorphisms [22]. Here, IL6 is linked to polycystic ovary syndrome.