TNF and obesity due to melanocortin 4 receptor deficiency: The results showed no significant association of the TNF-alpha (−308 G/A) polymorphism with obesity in patients with PCOS (BMI ≥ 25 kg/m2 vs. BMI < 25 kg/m2) (AA + GA vs. GG: OR = 0.94, 95% CI = 0.49–1.79; Figure 3).