CDKAL1 and type 2 diabetes mellitus: If differential CDKAL1-v1 expression was heavily involved in mediating the association between variants at the CDKAL1 locus and type 2 diabetes susceptibility, we would expect rs9366357, which explains a much larger amount of the variation in levels of CDKAL1-v1 compared with rs7756992, to be more strongly associated with type 2 diabetes risk.