During the 4 week intervention period following the onset of diabetes, the insulin-treated mice maintained on a HFD continued to gain weight, more body fat (Fig. 2A & B), and even higher fasting insulin, C-Peptide, and leptin levels (2C & D) whereas sham-treated diabetic mice showed a tendency to lose weight (Fig. 2A). The gene discussed is INS; the disease is diabetes mellitus.