In the present study, the expression of miR-21 and SPRY2 in myeloma cells was investigated and the results lay the foundation for the identification of the association of miR-21 and SPRY2 expression with the pathogenesis, progression and malignant characteristics of myeloma, as well as for the clarification of the transcriptional regulatory mechanism of miR-21 in myeloma cells. This evidence concerns the gene SPRY2 and plasma cell myeloma.