Increased demand for Cbl is believed to be supplied by two basic mechanisms: i) tumor cells themselves produce TCII that is then able to scavenge, bind, transport and deliver Cbl to the cells [20, 21], and ii) cell surface TCII-R levels are up-regulated to import more Cbl when the cells are in a proliferative mode [22, 23]. The gene discussed is CBL; the disease is neoplasm.