This finding suggests that malignant tumor types may possess characteristic metabolic profiles, and these profiles, in conjunction with immunohistochemical quantification of TCII, TCII-R and Ki-67 expression, may play an important role in establishing inclusion criteria for clinical trials evaluating Cbl-based anti-tumor agents and ultimately in selection of optimal treatment regimens with either single agent or combination therapies. This evidence concerns the gene MKI67 and neoplasm.