Similar to canine tissues, TCII staining values were higher than those observed for TCII-R in the majority of both malignant tumor and adjacent normal tissues: 81% of malignant tissues (median difference of 1.9 times greater) and 72% of normal tissues (median difference of 6.5 times greater) had higher TCII staining values compared to TCII-R staining values. The gene discussed is TCN2; the disease is neoplasm.