For example, down-regulation of Serpinh1, an ECM protease inhibitor involved in ECM degradation, implicated in osteogenesis imperfecta and encodes collagen chaperone protein Hsp47 [50] and up-regulation of Mmp8 - alleviating joint inflammation and bone erosion [51] coupled with down-regulation of Mmp10 involved in promoting cartilage degradation [52], respectively. The gene discussed is SERPINH1; the disease is osteogenesis imperfecta.