Loss of miR-29c expression is an early event in the initiation of gastric carcinogenesis.14 Our previous studies showed that miR-25 was overexpressed in plasma and primary tumor tissues of GC patients and that miR-25 promotes GC migration, invasion and proliferation by directly targeting transducer of ERBB2 and ERBB1.15 These studies suggested a close correlation between miRNAs and the development, progression, metastasis and prognosis of GC. The gene discussed is ERBB2; the disease is gastric cancer.