CTGF regulates cell adhesion, proliferation and migration, as a direct target of TAZ and TEAD.35 The ectopic expression results showed that overexpression of TAZ protein with pcDNA3.1-TAZ enhanced TAZ mRNA and protein levels and TAZ target CTGF protein levels and promoted cell proliferation, invasion and migration (Figures 5a–g), and, as predicted, TAZ and TAZ target CTGF expression were markedly decreased in the GC cells after transfection with miR-141 and were restored when the GC cells were cotransfected with pcDNA3.1-TAZ and miR-141 mimics (Figure 5h). Here, WWTR1 is linked to gastric cancer.