MAP2K3 and neoplasm: Moreover, MKK3 depletion induced cell autophagy that contributed to the degradation of mutp53, in agreement with recent studies.24, 27 Furthermore, at biological level, MKK3 depletion in combination with chemotherapy reduces clonogenicity in both wtp53 and mutp53 cancer cells and induced higher in vivo anti-tumoral effects in a xenograft tumor model, when compared with drug treatment alone.