TP53 and cancer: Our previous studies suggested MKK3 as a general molecular player required to sustain cell proliferation and survival not only in mutp53-bearing but also in p53-null cancer lines.9 Here, we wanted to evaluate whether MKK3 played a role also in wild-type (wt) p53-bearing cells and its impact on both mup53 and wtp53 tumor cell response to anticancer drugs, investigating the molecular mechanisms involved in the biological outcomes upon MKK3 depletion.