We previously showed that MKK3 is a general required factor to sustain cell proliferation and survival in mut- and null-p53 human cancer cell lines.9 Here, we aimed to explore whether MKK3 could have similar roles in wtp53 cell-context with a panel of human cancer (MFC7, HCT116) and primary non-transformed (FB1329, MCF10A) cell lines. Here, TP53 is linked to cancer.