Interestingly, we found that MKK3 deficiency induced, in wtp53-bearing cancer cells, an evident stabilization of p53 protein level that was straightly linked to ER stress induction, according to recent data.38 However, p53 stabilization does not contribute in p21 gene expression and authophagy as its depletion does not impact on the biological effects observed upon MKK3 depletion (Figures 2d and e and data not shown). The gene discussed is MAP2K3; the disease is cancer.