CTBP1 and neoplasm: MTOB (4-methylthio-2-oxobutanoate) is a proven inhibitor of CtBP function with observed effect in inhibiting the engrafted tumor growth.33 Importantly, MTOB was shown to directly inhibit the repressive function of CtBP.19, 33, 34 Thus, the MTOB function in affecting the intracellular metabolic homeostasis was investigated.