FLNC and familial dilated cardiomyopathy: In addition to finding several truncating mutations in established DCM genes (data not shown), we identified in one patient with severe DCM (left ventricular ejection fraction of 25% and incessant ventricular tachycardia) a novel splice acceptor mutation in FLNC (c.3791 - 1 G>C) that is predicted to lead to exclusion of a 53 amino acid exon and result in a frame shift.