Since in the previously described experiment (i.e., IM and RM HSC-3 monocultures in normoxic and hypoxic conditions) the CAV1-positive spindle-shaped cells were found in an intimate relation to the HSC-3 tumor clusters, we raised the possibility that the origin of these cells could be from HSC-3 cells that had undergone a process of epithelial-mesenchymal transition (EMT). The gene discussed is CAV1; the disease is neoplasm.