BCL2 and neoplasm: Tumor cells have evolved a variety of strategies to limit or circumvent apoptosis, including activation or enhanced expression of antiapoptotic factors (such as BCL-2, BCL-XL, and IAPs), inactivation of the master proapoptotic p53 pathway thus preventing upregulation of proapoptotic BCL-2 family proteins upon genotoxic stress [9, 10].