Later Fransen et al. suggested an alternative formulation of DAS28 based on C-reactive protein (DAS28-CRP) [7], since CRP is a preferential measure of inflammation compared to ESR [8, 9], with ESR being confounded by age, sex, anaemia, time of day, plasma viscosity, and abnormal shape and size of the red blood cells [8]. This evidence concerns the gene CRP and anemia.