ITIH4 and infection: An example of applying ISA in the area of drug discovery can be found in [16] where this technique was applied in development of HIV entry inhibitors and with such further potential applications in HIV/AIDS therapeutic interventions [46], outcome of which suggests targeting the variable region 3 (V3) of the HIV-1 gp120 at the early stage of the infection, which is expected to help potentially develop approaches to designing new HIV/AIDS therapeutic interventions.