GDNF has a potential therapeutic effect in different pathological paradigms, such as Parkinson's disease, brain ischemia, epilepsy and amyotrophic lateral sclerosis (ALS) (Acsadi et al., 2002; Airaksinen and Saarma, 2002; Krakora et al., 2013; Mohajeri et al., 1999; Moreno-Igoa et al., 2012). This evidence concerns the gene GDNF and amyotrophic lateral sclerosis.