APOA5 and coronary artery disorder: An assumption that the causal effect of triglycerides on CHD risk is independent of the effects of LDL-C and HDL-C may not be satisfied, particularly as evidenced by the attenuation of the observational association of triglycerides with CHD risk upon adjustment for HDL-C and non-HDL-C (21) and studies of the apolipoprotein A5 gene (APOA5) (35).