IDH2 and glioblastoma: Next, we confirmed the hypermethylated phenotype in GBM, also known as G-CIMP [20], and the hypermethylated phenotype in LAML, also known as L-CIMP characterized by IDH1 or IDH2 mutations [21] (Figure 1B,C; Figures S2, S3 and S4 in Additional file 1).