Analyses of non-synonymous variants also enable us to identify particular genes likely to underlie previously identified associations at six loci associated with FG and/or FI (G6PC2, GPSM1, SLC2A2, SLC30A8, RREB1 and COBLL1) and five with T2D (ARAP1, GIPR, KCNJ11, SLC30A8 and WFS1). This evidence concerns the gene KCNJ11 and type 2 diabetes mellitus.