The association of variation in GLP1R with FG and T2D represents another instance wherein genetic epidemiology has identified a gene that codes for a direct drug target in T2D therapy (incretin mimetics), other examples including ABCC8/KCNJ11 (encoding the targets of sulfonylureas) and PPARG (encoding the target of thiazolidinediones). The gene discussed is GLP1R; the disease is type 2 diabetes mellitus.