Analysis of western blot results revealed a significant decrease in CSPalpha levels in the mild Alzheimer’s disease hippocampus when normalized with synaptophysin (F(2,20 = 4.26; P < 0.05), but showed no difference when normalized with NSE (F(2,21 = 0.366, p = 0.427). This evidence concerns the gene SYP and early-onset autosomal dominant Alzheimer disease.