SOCS3 and asthma: SOCS1 through SOCS3 have been studied in detail, including development of knockout mice.18-20SOCS1 deletion causes fatal inflammation, which can be rescued by deletion of IFNG. 18In mice SOCS1 and SOCS2 negatively regulate TH2 immunity19,21-23; however, a human polymorphism enhancing SOCS1 expression is associated with asthma.24