SOCS1 and asthma: This strongly supports the idea that SOCS1 expression is likely to be further upregulated as asthma exacerbations progress, which is consistent with observations of substantially impaired interferon responses and greater viral replication in lung cells at later time points,6,7,13,14 increased duration of rhinovirus-related lower airways symptoms in asthmatic patients,4 and strong relationships between impaired interferon induction and asthma exacerbation severity in vivo.7