Two recent studies reported that exogenous TGF-β enhanced rhinovirus replication in fibroblasts and BECs and that this was accompanied by reduced interferon levels.16,17 The latter study also reported that anti–TGF-β treatment of BECs from asthmatic patients was accompanied by reduced suppressor of cytokine signaling (SOCS) 1 and SOCS3 gene expression,17 possibly associating these SOCS proteins with interferon deficiency, but no investigations of SOCS function were performed. This evidence concerns the gene CISH and hyperinsulinemic hypoglycemia, familial, 4.