There was a positive correlation between SOCS1 staining scores and numbers of positive skin prick test responses, with a similar nonsignificant trend for IgE levels (data not shown) and a negative correlation with the provocative concentration of histamine causing a 20% reduction in lung function (PC20 histamine), indicating greater intensity of SOCS1 staining was related to greater severity of atopy and airway hyperresponsiveness (Fig 2, B). Here, SOCS1 is linked to airway hyperresponsiveness.