The susceptibility of pancreatic cancer-derived cell lines to H-1PV infection was reported to correlate with the expression of functional SMAD4, a transcription factor which is involved in the regulation of the tumor growth factor β (TGF-β) signaling pathway [92], and whose gene is mutated in about 50% of pancreatic carcinomas. This evidence concerns the gene SMAD4 and familial pancreatic carcinoma.