Furthermore, it has been reported that MAPK/ERK activity modulates miRNA biogenesis in cancer cell lines by phosphorylating TAR RNA binding protein (TRBP) and stabilizing the Dicer-TRBP complex which enhances mature miRNA production, whereas pharmacological inhibition of MAPK/ERK decreases growth-promoting miRNAs and increased growth-suppressive miRNAs [27]. The gene discussed is MAPK1; the disease is cancer.