The rates of remission and response in the current observational study were somewhat higher than those obtained in ADACTA, possibly reflecting the fact that patients in the latter trial had more severe RA overall than those in our trial (DAS28 6.7 in ADACTA vs. around 5.3 in the current study) and the patients treated with monotherapy in CONSENS were DMARD and/or TNF-IR. The gene discussed is TNF; the disease is rheumatoid arthritis.