In contrast to the widespread expression of Sox10 displayed by mouse naevi and melanoma tissue (Fig. 3B,D, [9]), immunostaining of both naevi and primary melanoma sections did not reveal any detectable expression of Sox9 protein (Fig. 3A,C; S4B Fig.), consistent with the data that we have obtained for human giant congenital naevi and melanoma (Fig. 1H-I). Here, SOX10 is linked to melanoma.