Fig. 1B shows expression of the p53 tumor suppressor gene (which is activated by hyperglycemia and affects TauT transcription) and TauT in both non-diabetic and diabetic WT and TauT+/- mice. Previous studies have shown that activation of p53 down-regulates TauT expression in renal cells both in vitro and in vivo (Han 2002 and 2009). The present results confirmed the genotypes of TauT-deficient mice used for the current study and the down-regulation of TauT in vivo in diabetic mice, particularly in TauT+/- diabetic mice at 5 months after DM induction (Fig. 1C and D). Here, SLC6A6 is linked to diabetes mellitus.