In attempt to elucidate the molecular mechanism of Dsg3-dependent tumour cell migration a recent study by Chen et al. suggests that Dsg3 negatively regulates Wnt/β-catenin signalling in a Pg-dependent manor, most likely by sequestering Pg preventing its nuclear translocation and suppression of LEF/TCF transcriptional activity [59]. Here, HNF4A is linked to neoplasm.