Adopting a gain-of-function approach, overexpression of wild type human Dsg3 in A431 and SqCC/Y1 carcinoma cell lines has been shown to significantly increase cell spreading, membrane protrusion and dynamics as well as cell migration and invasion, a phenotype that could be suppressed by Dsg3 silencing [56,57,58]. The gene discussed is DSG3; the disease is carcinoma.