Moreover, it has been established that eHSP90 binds the extracellular sub-domain II of LRP-1 and activates downstream AKT1 and AKT2 kinase signaling pathways through the cytoplasmic NPVY motif of LRP-1, thus promoting cell motility and being essential for wound healing as well as tumor invasion [186]. This evidence concerns the gene LRP1 and neoplasm.