AKT1 and cancer: In this context, during glioblastoma cell invasion, eHSP90-LRP1-mediated AKT signaling, necessitates the interaction of LRP-1 with pro-motility receptor tyrosine kinase EphA2 whose over-expression is common in cancers and is associated with oncogenic activity, cell invasiveness, metastatic potential and poor prognosis [188,189] (Figure 4B).