Single measurements of NT-proBNP have shown strong prognostic value for cardiovascular events (CVE), all-cause and CVD-specific mortality or heart failure (HF) in cardiac patients[4,5,6] as well as in the general population[7,8], providing modest improvements in risk discrimination after adjustment for conventional cardiovascular (CV) risk factors[9]. The gene discussed is NPPB; the disease is hydrops fetalis.