NPPB and hydrops fetalis: Among 756 older men with CVD but without overt HF participating in the British Regional Heart Study, high levels of NT-proBNP were associated with major CVE, CV mortality, major CHD events, and fatal CHD after adjustment for traditional CV risk factors, with a statistically significant improvement of NRI[24], while baseline NT-proBNP levels showed a prognostic value with respect to long-term mortality after adjustment for conventional CV risk factors and the degree of LV function among 1034 patients with stable CHD[25].