The LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre transgenic mouse model (TrM mice) has mutations in Kras and p53, leading to spontaneous development of pancreatic cancer [17], that recapitulates pancreatic cancer in humans [35]. The gene discussed is TP53; the disease is pancreatic neoplasm.