As any association has been detected at these CRIPTO associated loci in large-scale cancer GWAS, further studies looking at CRIPTO variability in serum together with genotyping of the functional variant in specific cohorts of patients, focusing the analysis on specific cancer phenotypes, as metastasis formation, aggressiveness, prognosis, would be useful to better investigate possible associations between variants modulating CRIPTO protein levels and cancer features. The gene discussed is CRIPTO; the disease is cancer.